GLP-1 medications like semaglutide and tirzepatide can reduce appetite while supporting blood sugar control and metabolic health. These shifts often lead to lower overall food intake, making it important to intentionally support nutrition, strength, and hydration. This article outlines three foundational pillars; strength training, protein- and fiber-focused nutrition, and hydration, to help maintain muscle, support nutrient needs, and promote overall health while using GLP-1 medications.